Cortical complexity as a measure of age-related brain atrophy

Cortical complexity as a measure of age-related brain atrophy

The structure of the human brain changes in a variety of ways as we age. While a sizeable literature has examined age-related differences in cortical thickness, and to a lesser degree, gyrification, here we examined differences in cortical complexity, as indexed by fractal dimensionality in a sample of over 400 individuals across the adult lifespan. While prior studies have shown differences in...

Madan, Christopher R. and Kensinger, Elizabeth A. (2016) Cortical complexity as a measure of age-related brain

26 The structure of the human brain changes in a variety of ways as we age. While a sizeable 27 literature has examined age-related differences in cortical thickness, and to a lesser 28 degree, gyrification, here we examined differences in cortical complexity, as indexed by 29 fractal dimensionality in a sample of over 400 individuals across the adult lifespan. While 30 prior studies have shown...

Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease.

Cerebral volume loss has long been associated with normal aging, but whether this is due to aging itself or to age-related diseases, including incipient Alzheimer disease, is uncertain. To understand the changes that occur in the aging brain, we examined the cerebral cortex of 27 normal individuals ranging in age from 56 to 103 years. None fulfilled the criteria for the neuropathologic diagnosi...

NSAIDs May Protect Against Age-Related Brain Atrophy

The use of non-steroidal anti-inflammatory drugs (NSAIDs) in humans is associated with brain differences including decreased number of activated microglia. In animals, NSAIDs are associated with reduced microglia, decreased amyloid burden, and neuronal preservation. Several studies suggest NSAIDs protect brain regions affected in the earliest stages of AD, including hippocampal and parahippocam...

Sensing as a Complexity Measure